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王建
2012-04-25 17:19:47   浏览次数:0  文字大小:【】【】【

欢迎来到相互作用实验室

 

平台研究方向

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     实验室主要关注两个方向:(1人类肝脏蛋白质相互作用连锁图;(2新的免疫信号通路的调控分子在炎症和肿瘤等疾病过程中的功能和作用机制。欢迎国内外科研工作者加盟或合作研究!

发表论文:

1.     Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J (2011) Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells. FEBS Lett

2.     Yu M, Li H, Liu Q, Liu F, Tang L, Li C, Yuan Y, Zhan Y, Xu W, Li W, Chen H, Ge C, Wang J, Yang X (2011) Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 23: 883-892

3.     Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (2011) SCFFBXL(1) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J 30: 2675-2689

4.     Guo X, Shen S, Song S, He S, Cui Y, Xing G, Wang J, Yin Y, Fan L, He F, Zhang L (2011) The E3 ligase smurf1 regulates wolfram syndrome protein stability at the endoplasmic reticulum. J Biol Chem 286: 18037-18047

5.     Zhang Y, Wang J, Yuan Y, Zhang W, Guan W, Wu Z, Jin C, Chen H, Zhang L, Yang X, He F (2010b) Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic Acids Res 38: 6544-6554

6.     Zhang W, Wang J, Zhang Y, Yuan Y, Guan W, Jin C, Chen H, Wang X, Yang X, He F (2010a) The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1. Mol Biol Cell 21: 2500-2513

7.     Guo L, Ying W, Zhang J, Yuan Y, Qian X, Wang J, Yang X, He F (2010) Tandem affinity purification and identification of the human TSC1 protein complex. Acta Biochim Biophys Sin  42: 266-273

8.     Li S, Lu K, Wang J, An L, Yang G, Chen H, Cui Y, Yin X, Xie P, Xing G, He F, Zhang L (2010) Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. Mol Cell Biochem 338: 11-17

9.     Nie J, Wu M, Wang J, Xing G, He F, Zhang L (2010) REGgamma proteasome mediates degradation of the ubiquitin ligase Smurf1. FEBS Lett 584: 3021-3027

10.  Liu Q, Chen Q, Wang J, Zhang Y, Zhou Y, Lin C, He W, He F, Xu D (2010) A miniaturized sandwich immunoassay platform for the detection of protein-protein interactions. BMC Biotechnol 10: 7

11.  Wu Z, Zhang X, Yang J, Wu G, Zhang Y, Yuan Y, Jin C, Chang Z, Wang J, Yang X, He F (2009) Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochem Biophys Res Commun 387: 348-352

12.  Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L, He F (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11: 580-591

13.  Liu W, Li D, Wang J, Xie H, Zhu Y, He F (2009) Proteome-wide prediction of signal flow direction in protein interaction networks based on interacting domains. Mol Cell Proteomics 8: 2063-2070

14.  Sun H, Li D, Wang J, Liu Z, Zhu Y, Xie H, He F (2009) PNmerger: a Cytoscape plugin to merge biological pathways and protein interaction networks. Prog Biochem Biophy 36: 1613-1616

15.  Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F (2008) Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res 7: 3879-3889

16.  Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (2008) E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal 20: 942-948

17.  Yu M, Wang J, Li W, Yuan YZ, Li CY, Qian XH, Xu WX, Zhan YQ, Yang XM (2008) Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha. Nucleic Acids Res 36: 1209-1219

18.  Li D, Liu W, Liu Z, Wang J, Liu Q, Zhu Y, He F (2008) PRINCESS, a protein interaction confidence evaluation system with multiple data sources. Mol Cell Proteomics 7: 1043-1052

19.  Pan Z, Wang J, Yin X, Xie P, Yang J, Jiang J, Zhang L, He F (2008) The function study on the interaction between Grb2 and AMPK. Mol Cell Biochem 307: 121-127

20.  Zhang L, Tang Y, Tie Y, Tian C, Wang J, Dong Y, Sun Z, He F (2007) The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Cell Signal 19: 932-944

21.  Li D, Li J, Ouyang S, Wang J, Wu S, Wan P, Zhu Y, Xu X, He F (2006) Protein interaction networks of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster: large-scale organization and robustness. Proteomics 6: 456-461

22.  Li D, Li J, Ouyang S, Wu S, Wang J, Xu X, Zhu Y, He F (2005) An integrated strategy for functional analysis in large scale proteomic research by gene ontology. Prog Biochem Biophy 32: 1026-1029

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