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张普民

军事医学科学院放射与辐射医学研究所研究员、博士生导师

北京蛋白质组研究中心副主任

邮箱:pzhangbcmedu@gmail.com

 

研究方向:

 

    张普民博士长期从事人类疾病包括肝脏疾病和癌症的分子遗传学研究,在细胞周期,遗传发育,基因组稳定性等方面有较深的造诣。2011年加入北京蛋白质组研究中心后,展开了蛋白质组学的相关研究。其实验室开发了在成鼠肝内进行基因操作的技术方法,为功能发掘肝蛋白质组奠定了基础。目前正在进行肝转录因子和泛素连接酶的功能筛选。

 

发表文献:

 

1.      Li, M., Shin, Y. H., Lin, F., Klann, E. and Zhang, P. (2008). The adaptor protein of the anaphase promoting complex Cdh1 plays an essential role in maintaining replicative life span and in learning and memory. Nat Cell Biol. 10, 1083-3089.

2.      Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, and Zhang, P. (2008). Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 6, e15.

3.      Li, M., Fang, X., Wei, Z., York, J. P. and Zhang, P. (2009). Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J. Cell Biol. 185, 983-994.

4.      Huang X, Andreu-Vieyra CV, Wang, M., Cooney, A., Matzuk MM, and Zhang, P. (2009) Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.  Mol. Cell Biol. 29, 1498–1505.

5.      Li, M. Fang, X., Baker, D.J., Guo, L., Gao, X., Wei, Z., Han, S., van Derusen, J., and Zhang, P.  (2010). The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis in mice. Proc Natl Acad Sci USA. 107: 14188-93.

6.      Gao, X., Shin, Y. H., Li, M., Wang, F., Tong, Q., and Zhang, P.  (2010). The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE. 5: e14005.

7.      Fang, X. and Zhang, P. (2011). Aneuploidy and tumorigenesis. Semin. Cell Dev. Biol. 22(6): 595-601. PMID: 21392584.

8.      Zhang, W., Peng, G., Lin, S. Y., and Zhang, P. (2011) DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J. Biol. Chem. 286(41): 35899-905. PMID: 21878640.

9.      Wei, Z., Peddibhotla, S., Lin, H., Fang, X., Li, M., Rosen, J. M., and Zhang, P. (2011). Early onset aging and defective DNA damage response in Cdc14b-deficient mice.  Mol. Cell Biol. 31: 1470-7.

10.   Shen, B., Zhang, J., Wu, H., Wang, J., Ma K, Li, Z., Zhang, X., Zhang, P, Huang X. (2013) Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res. 23:720-3.

 


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