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朱云平

军事医学科学院放射与辐射医学研究所研究员,硕士生导师

北京蛋白质组研究中心、蛋白质组学国家重点实验室

生物信息学研究课题组长

邮箱:zhuyunping@gmail.com

 

研究方向:

 

从事蛋白质组生物信息学及肝脏系统生物学研究。在大规模蛋白质组数据质量控制、不同实验室来源数据整合和标准建立、大规模蛋白质组数据分析策略等方面发展了可应用的技术体系和软件平台,将质谱数据利用率提升了20%~40%;建立了系列肝脏蛋白质组数据库;提出了描述信号转导网络节点重要性的方法;通过对生物学网络中信号流方向的研究,可推断出蛋白质相互作用网络中大量的潜在信号通路;参与中国肝脏蛋白质组计划并提供了有力的生物信息学支持。承担国家973/863课题、创新群体课题、国家自然科学基金课题、北京市重大研究项目课题等多项科研项目。获国家科技进步奖三等奖、北京市科学技术奖一等奖等共4项;获软件著作权8项,在Mol Cell Proteomics, J Proteome Res, Proteomics, BMC Bioinformatics等国内外杂志发表论文70余篇。

 

发表文献:

 

1.      1.  Wu S, Li N, Ma J, Shen H, Jiang D, Chang C, Zhang C, Li L, Zhang H, Jiang J, Xu Z, Ping L, Chen T, Zhang W, Zhang T, Xing X, Yi T, Li Y, Fan F, Li X, Zhong F, Wang Q, Zhang Y, Wen B, Yan G, Lin L, Yao J, Lin Z, Wu F, Xie L, Yu H, Liu M, Lu H, Mu H, Li D, Zhu W, Zhen B, Qian X, Qin J, Liu S, Yang P, Zhu Y, Xu P, He F.      First proteomic exploration of protein-encoding genes on chromosome 1 in human liver, stomach, and colon. J Proteome Res. 2013, 12(1):67-80.

2.      Ma J, Li W, Lv Y, Chang C, Wu S, Song L, Ding C, Wei H, He F, Jiang Y, Zhu Y. A new insight into the impact of different proteases on SILAC quantitative proteome of the mouse liver. Proteomics. 2013, May 22. [Epub ahead of print].

3.      Zhang Y, Yang C, Wang S, Chen T, Li M, Wang X, Li D, Wang K, Ma J, Wu S, Zhang X, Zhu Y, Wu J, He F. LiverAtlas: a unique integrated knowledge database for systems-level research of liver and hepatic disease. Liver Int. 2013, [Epub ahead of print].

4.      Li N, Wu S, Zhang C, Chang C, Zhang J, Ma J, Li L, Qian X, Xu P, Zhu Y, He F. PepDistiller: A quality control tool to improve the sensitivity and accuracy of peptide identifications in shotgun proteomics. Proteomics. 2012, 12(11): 1720-5.

5.      Zhang Y, Wang S, Li D, Zhang J, Gu D, Zhu Y, He FC. A Systems Biology-Based Classifier for Hepatocellular Carcinoma Diagnosis. PLOS One. 2011, 6(7): e22426.

6.      Ma J, Zhang J, Wu S, Li D, Zhu Y*, He F*. Improving the sensitivity of MASCOT search results validation by combining new features with Bayesian nonparametric model. Proteomics. 2010, 10(23):4293-300.

7.      Liu W, Li D, Wang J, Xie H, Zhu Y, He F. Proteome-wide prediction of signal flow direction in protein interaction networks based on interacting domains. Mol Cell Proteomics. 2009, 8(9):2063-70.

8.      Zhang Jiyang, Ma Jie, Dou Lei, Wu Songfeng, Qian Xiaohong, XieHongwei, Zhu Yunping, He Fuchu. Bayesian nonparametric model for the validation of peptide identification in shotgun proteomics. Mol Cell Proteomics. 2009, 8:547-57.

9.      Zhang J, Ma J, Dou L, Wu S, Qian X, Xie H, Zhu Y, He F. Mass measurement errors of Fourier-transform mass spectrometry (FTMS): distribution, recalibration, and application. J Proteome Res. 2009, 8(2):849-859.

10.   Dong Li, Wanlin Liu, Zhongyang Liu, Jian Wang, Qijun Liu, Yunping Zhu and Fuchu He. PRINCESS: a PRoteinINteraction Confidence Evaluation System with multiple data Sources. Mol Cell Proteomics. 2008, 7:1043–52.

 


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