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钱小红

军事医学科学院放射与辐射医学研究所研究员,博士生导师

北京蛋白质组研究中心技术总监

蛋白质组学国家重点实验室副主任

中国生物化学与分子生物学会蛋白质组学专业委员会(CNHUPO)副理事长,中国物理学会质谱分会副理事长,中国化学会质谱分析专业委员会副理事长,中国生物化学与分子生物学会常务理事,中国色谱学会理事,ProteomicsFrontiers in Biology、分析化学、色谱、质谱学报编委

邮箱:qianxh1@163.com

 

研究方向:

主要从事蛋白质组学技术研究及应用,生物质谱及其相关技术应用。建立了高灵敏度和高分辨率的规模化蛋白质组研究支撑技术体系,研究和设计了多种成熟的蛋白质组研究整体技术流程,规模化分离鉴定了人胎肝、法国人肝和中国成人肝脏蛋白质组。发展了多项自主创新的蛋白质组研究新技术新方法,建立高分辨率、高准确度、高灵敏度和高通量的蛋白质组表达谱、修饰谱研究技术平台;构建人体重要器官和体液的表达谱、修饰谱;建立和发展定量蛋白质组学策略用于发现和鉴定肝脏疾病早期诊断的生物标志物。

 

发表文献:

 

1.     Chen Ding, Jing Jiang, Junying Wei, Wanlin Liu, Wei Zhang, Mingwei Liu, Tianyi Fu, Tianyuan Lu, Lei Song, Wantao Ying, Cheng Chang, Yangjun Zhang, Jie Ma, Lai Wei, Anna Malovannaya, LijunJia, Bei Zhen, Yi Wang, Fuchu He, Xiaohong Qian, and Jun Qin. A Fast Workflow for Identification and Quantification of Proteomes. Molecular and Cellular Proteomics. 2013, 12(8): 2370–2380.

2.     Wanjun Zhang, Huanhuan Han, HaihongBai, Wei Tong, Yangjun Zhang, Weijie Qin, and Xiaohong Qian. A Highly Efficient and Visualized Method for Glycan Enrichment by Self-Assembling Pyrene Derivative Functionalized Free Graphene Oxide. Analytical Chemistry. 2013, 85(5): 2703–2709.

3.     Quanhui Wang, Bo Wen,Guangrong Yan,Junying Wei,LiqiXie,Shaohang Xu, Dahai Jiang, Tingyou Wang, Liang Lin, Jin Zi, Ju Zhang, Ruo Zhou, Haiyi Zhao, ZheRen, NengrongQu, Xiaomin Lou, Haidan Sun, Chaoqin Du, Chuangbin Chen, Shenyan Zhang, Fengji Tan, Youqi Xian, Zhibo Gao, Minghui He, Longyun Chen, Xiaohang Zhao, Ping Xu, Yunping Zhu, Xingfeng Yin, Huali Shen, Yang Zhang, Jing Jiang, Chengpu Zhang, Liwei Li, Cheng Chang, Jie Ma, Guoquan Yan, Jun Yao, Haojie Lu, Wantao Ying, Fan Zhong, Qing-Yu He, and Siqi Liu. Qualitative and Quantitative Expression Status of the Human Chromosome 20 Genes in Cancer Tissues and the Representative Cell Lines. Journal of Proteome Research. 2013, 12(1): 151-161.

4.     Yulin Sun, Guangzhou Gao, JianqiangCai, Youliang Wang, XiuhuaQu, Lidong He, Fang Liu, Yangjun Zhang, Kaixuan Lin, Shouzhi Ma, Xiao Yang, Xiaohong Qian and Xiaohang Zhao. Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. Carcinogenesis. 2013, 34(3): 595–604.

5.     Xinyuan Zhao, Cheng Ma, Huanhuan Han, Jing Jiang, Fang Tian, Jifeng Wang, Wantao Ying, Xiaohong Qian. Comparison and optimization of strategies for a more profound profiling of the sialylated N-glycoproteomics in human plasma using metal oxide enrichment. Analytical and Bioanalytical Chemistry. 2013, 405(16): 5519-5529.

6.     Hongjun Lin, Yingfu Liu, JingruiHuo, Aihong Zhang, Yiting Pan, HaihongBai, Jiao Zhang, Tian Fang, Xin Wang, Yun Cai, Qingming Wang, Yangjun Zhang, and Xiaohong Qian. Modified Enzyme-Linked Immunosorbent Assay Strategy Using Graphene Oxide Sheets and Gold Nanoparticles Functionalized with Different Antibody Types. Analytical Chemistry. 2013, 85(13): 62286232.

7.     Xueying Wang, Xin Wang, Weijie Qin, Hongjun Lin, Jifeng Wang, Junying Wei, Yangjun Zhang and Xiaohong Qian. Metal–tag labeling coupled with multiple reaction monitoring-mass spectrometry for absolute quantitation of proteins. Analyst. 2013, 138(18): 5309-5317.

8.     Cheng Ma, Xinyuan Zhao, Huanhuan Han, Wei Tong, Qi Zhang, Peibin Qin, Cheng Chang, Bo Peng, Wantao Ying, Xiaohong Qian. N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis. 2013, 34(16): 2440- 2450.

9.     Yiting Pan, HaihongBai, ChengMa, YulinDeng, WeijieQin, XiaohongQian. Brush polymer modified and lectin immobilized core–shell microparticle for highly efficient glycoprotein /glycopeptide enrichment. Talanta. 2013, 115, 842–848.

10. HaihongBai, YitingPan, WeiTong, WanjunZhang, XiaojunRen, FangTian, Bo Peng, XinWang, YangjunZhang, YulinDeng, WeijieQin, XiaohongQian. Graphene based soft nanoreactors for facile “one-step” glycan enrichment and derivatization for MALDI-TOF-MS analysis. Talanta. 2013, 117, 1-7.

 


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