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裴华东

军事医学科学院放射与辐射医学研究所研究员

北京蛋白质组研究中心DNA损伤修复研究课题组长、博士生导师

国家“青年千人计划”入选者及“北京市青年海聚人才计划”资助对象

 

研究方向:

 

主要利用生化与分子遗传学技术,从事DNA损伤修复应答与基因组不稳定性及肿瘤成因分子机理研究。近年来又开展了肿瘤细胞代谢调控研究。以第一作者或者通讯作者在NatureCancer Cell 等杂志发表论文10余篇,他引逾300次。 

 

发表文献:

 

1.      Zhang haoxin, Liu hailong, li chaoqun , Lou Zhenkun and Pei H. UHRF1 Antagonizes RIF1and Regulates DNA Break Repair Pathway Choice. Under Review in Cell. (corresponding author)

2.      Xu Qiuran, Xin Liu, Caihong Yang, Yu Du, Tongzheng Liu, Qingguang Liu, Zhenkun Lou and Pei H. AMPK regulates Histone H2B O-GlcNAcylation during gene transcription. Nucleic Acids Research. 2014, in Press (corresponding author)

3.      Pei H, Xiaosheng Wu, Tongzheng Liu, Kefei Yu, Diane F. Jelinek and Zhenkun Lou. The histone methytransferase MMSET regulates class-switch recombination. J Immunol. 2013 Jan 15;190(2):756-63.

4.      Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Leifbergsagel P, Wang L, You Z, Lou Z. Histone methyltransferase MMSET regulates histone H4 Lysine 20 methylation and 53BP1 accumulation at DNA damage sites. Nature.  2011 Feb 2; 470:124-8.

5.      Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009; 16(3):259-66.

6.      Comment in: Cancer Cell. 2009 Sep 8; 16(3):178-80.

7.      Pei H, Lou Z, Wang L. Emerging role of FKBP51 in AKT kinase/protein kinase B signaling. Cell Cycle. 2010 Jan 1; 9(1):6-7.

8.      Pei H, Liu J, Li J, Guo A, Zhou J, Xiang H. Mechanism for the TtDnaA-Tt-oriC cooperative interaction at high temperature and duplex opening at an unusual AT-rich region in Thermoanaerobacter tengcongensis. Nucleic Acids Res. 2007; 35(9):3087-99.

9.      Pei H, Liu J, Cheng Y, Sun C, Wang C, Lu Y, Ding J, Zhou J, Xiang H. Expression of SARS-coronavirus nucleocapsid protein in Escherichia coli and Lactococcus lactis for serodiagnosis and mucosal vaccination. Appl Microbiol Biotechnol. 2005; 68(2):220-7

10.   Liu J, Pei H, Mei S, Li J, Zhou L, Xiang H. Replication initiator DnaA interacts with an anti-terminator NusG in T. tengcongensis. Biochem Biophys Res Commun. 2008 Jul 4; 371(3):573-7.

11.   Liu J, Li J, Wu Z, Pei H, Zhou J, Xiang H. Identification and Characterization of the Cognate Anti-Sigma Factor and Specific Promoter Elements of a T. tengcongensis ECF Sigma Factor. PLoS One. 2012; 7(7):e40885.

 

 


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