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杨晓明

军事医学科学院放射与辐射医学研究所所长,研究员,博士生导师

北京蛋白质组研究中心理事,相互作用研究课题组长

蛋白质组学国家重点实验室副主任

邮箱: xiaomingyang@sina.com

 

研究方向:

 

从事肝脏相关的生理病理学研究,重点是肝细胞生长调控的分子机制研究。建立了具有国际先进水平的蛋白质相互作用研究技术平台,构建了国际上最大规模的人类器官蛋白质相互作用数据库和相互作用网络,首次探索用相互作用网络诠释器官功能调控特点,揭示多种重要信号通路的节点及生理、病理学意义,预测了多种严重肝病获选致病分子。首次证实人肝活素(HPS)是内源性肝损伤修复因子,重组HPS可有效保护中毒性肝损伤,揭示HNF1是其肝特异表达的关键调控分子,为严重肝病治疗提供获选药物。HPS作为治疗肝损伤药物,列入国家新药创制重大专项获滚动支持,并以2600万转让企业,目前到位经费1000万元。此外,还揭示多种调控肝源细胞生长的新分子和新机制,发现THAP11PCBP1HPO等可作为肝癌诊断、治疗的获选新靶点。此外,还开展了造血调控转录因子的研究,揭示了一种新的可调控造血干细胞谱系分化的转录调节因子EDAG,并探讨了其作用机制。承担国家自然科学基金重点项目、创新群体项目、国家973/863项目等多项科研项目。获国家创新团队奖,国家科技进步奖二等奖、军队科技进步奖一等奖、北京市科技进步一等奖等5项;获中国发明专利3项,在PNASGutMolSystBiolCell Death Differ等国内外杂志发表论文100余篇。

 

发表文献:

 

1.      Li, C.Y., C.Z. Cao, W.X. Xu, M.M. Cao, F. Yang, L. Dong, M. Yu, Y.Q. Zhan, Y.B. Gao, W. Li, Z.D. Wang, C.H. Ge, Q.M. Wang, R.Y. Peng, and X.M. Yang. 2010. Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. Gut. 59:817-826.

2.      Wang, J., K. Huo, L. Ma, L. Tang, D. Li, X. Huang, Y. Yuan, C. Li, W. Wang, W. Guan, H. Chen, C. Jin, J. Wei, W. Zhang, Y. Yang, Q. Liu, Y. Zhou, C. Zhang, Z. Wu, W. Xu, Y. Zhang, T. Liu, D. Yu, L. Chen, D. Zhu, X. Zhong, L. Kang, X. Gan, X. Yu, Q. Ma, J. Yan, L. Zhou, Z. Liu, Y. Zhu, T. Zhou, F. He, and X. Yang. 2011. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 7:536.

3.      Zhang, Y., J. Wang, Y. Yuan, W. Zhang, W. Guan, Z. Wu, C. Jin, H. Chen, L. Zhang, X. Yang, and F. He. 2010. Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic Acids Res. 38:6544-6554.

4.      Zhang, W., J. Wang, Y. Zhang, Y. Yuan, W. Guan, C. Jin, H. Chen, X. Wang, X. Yang, and F. He. 2010. The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1. Mol Biol Cell. 21:2500-2513.

5.      Yu, M., H.X. Guo, C. Hui, X.H. Wang, C.Y. Li, Y.Q. Zhan, C.H. Ge, and X.M. Yang. 2013. 14-3-3zeta interacts with hepatocyte nuclear factor 1alpha and enhances its DNA binding and transcriptional activation. Biochim Biophys Acta. 1829:970-979.

6.      Zhang, M.J., Y.L. Ding, C.W. Xu, Y. Yang, W.X. Lian, Y.Q. Zhan, W. Li, W.X. Xu, M. Yu, C.H. Ge, H.M. Ning, C.Y. Li, and X.M. Yang. 2012. Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis. FEBS J. 279:2848-2862.

7.      Yu, M., H. Li, Q. Liu, F. Liu, L. Tang, C. Li, Y. Yuan, Y. Zhan, W. Xu, W. Li, H. Chen, C. Ge, J. Wang, and X. Yang. 2011. Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal. 23:883-892.

8.      Yang, H., Y. Ke, J. Wang, Y. Tan, S.K. Myeni, D. Li, Q. Shi, Y. Yan, H. Chen, Z. Guo, Y. Yuan, X. Yang, R. Yang, and Z. Du. 2011. Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network. Infect Immun. 79:4413-4424.

9.      Yao, J.W., J. Liu, X.Z. Kong, S.G. Zhang, X.H. Wang, M. Yu, Y.Q. Zhan, W. Li, W.X. Xu, L.J. Tang, C.H. Ge, L. Wang, C.Y. Li, and X.M. Yang. 2012. Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against oxidative stress-induced cell death. ToxicolApplPharmacol. 259:227-235.

10.   Zhang, T., X.H. Huang, L. Dong, D. Hu, C. Ge, Y.Q. Zhan, W.X. Xu, M. Yu, W. Li, X. Wang, L. Tang, C.Y. Li, and X.M. Yang. 2010. PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. Mol Cancer. 9:72.

 


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