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秦 钧

军事医学科学院放射与辐射医学研究所研究员,博士生导师

北京蛋白质组研究中心主任,网络与信号转导研究课题组长

蛋白质组学国家重点实验室副主任

邮箱:jqin@bcm.edu

 

研究方向:

 

    秦钧博士,著名的生物质谱学家和生物化学家,美国贝勒医学院教授,分子研究与通路发现中心主任,“千人计划”引进学者,北京市“海聚工程”入选者。在质谱仪器设计、蛋白质组研究方法进展和生物研究等领域有较深的造诣,尤其在DNA损伤反应、大规模转录调控研究、通过分离鉴定内源性蛋白质复合体发现核激素,鉴定体内翻译后修饰并诠释功能特性等方面有突出贡献。

 

发表文献:

 

1.      Malovannaya A, Lanz RB, Jung SY, Bulynko Y, Le NT, Chan DW, Ding C, Shi Y, Yucer N, Krenciute G, Kim BJ, Li C, Chen R, Li W, Wang Y, O'Malley BW, Qin J.Analysis of the human endogenous coregulator complexome. Cell. 2011, 145(5):787-99.

2.      Ding C, Chan DW, Liu W, Liu M, Li D, Song L, Li C, Jin J, Malovannaya A, Jung SY, Zhen B, Wang Y, Qin J.Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements. ProcNatlAcadSci U S A. 2013, 110(17):6771-6.

3.      Liu Q, Ding C, Liu W, Song L, Liu M, Qi L, Fu T, Malovannaya A, Wang Y, Qin J, Zhen B. In-depth proteomic characterization of endogenous nuclear receptors in mouse liver. Mol Cell Proteomics. 2013, 12(2):473-84.

4.      Ding C, Jiang J, Wei J, Liu W, Zhang W, Liu M, Fu T, Lu T, Song L, Ying W, Chang C, Zhang Y, Ma J, Wei L, Malovannaya A, Jia L, Zhen B, Wang Y, He F, Qian X, Qin J.A fast workflow for identification and quantification of proteomes.Mol Cell Proteomics. 2013, 12(8):2370-80.

5.      Krenciute G, Liu S, Yucer N, Shi Y, Ortiz P, Liu Q, Kim BJ, Odejimi AO, Leng M, Qin J, Wang Y.Nuclear BAG6-UBL4A-GET4 Complex Mediates DNA Damage Signaling and Cell Death. J Biol Chem. 2013, Jul 12;288(28):20547-57.

6.      Anna Malovannaya, Rainer B. Lanz1, Sung Yun Jung, Yaroslava Bulynko1, Nguyen T. Le, Doug W. Chan, Chen Ding, Yi Shi, NurYucer, GiedreKrencuite, Beom-Jun Kim, Chunshu Li, Yi Wang, Bert W. O’Malley*, Jun Qin*. Analysis of the Endogenous Human CoregulatorComplexome. Cell. 2011, 145( 5):787-99.

7.      Zhang J, Shi X, Li Y, Kim BJ, Jia J. Huang Z, Yang T, Fu X, Jung SY, Wang Y. Zhang P, Kim ST, Pan X, and Qin J*. (2008) Acetylation of Smc3 by Eco1 is required for S-phase sister chromatid cohesion in both human and yeast. Mol. Cell. 31(1):143-51.

8.      Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J*, Su B*. (2006) SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Cell. 127 (1), 125-37.

9.      Yazdi P, Wang Y. Song Z. Patel N, Lee E. Y.-H. P. and Qin J* (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16, 571-582.

10.   Wang, Y., Cortez, D., Yazdi, P., Neff, N. Elledge, S. J. and Qin, J*. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structure. Genes Dev. 14, 927-939.

 


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