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贺福初

中国科学院院士

发展中国家科学院院士

北京蛋白质组研究中心理事长

蛋白质组学国家重点实验室主任

人类蛋白质组计划国际执委会成员

亚太蛋白质组组织主席

邮箱:hefc@nic.bmi.ac.cn

 

研究方向:

 

    贺福初院士主要从事基因组学、蛋白质组学、生物信息学与系统生物学研究,倡导并领衔了人类第一个组织、器官的“肝脏蛋白质组计划”,这也是中国第一次领导大型国际合作计划,NatureScienceNat Biotechnol等国际著名杂志给予高度评价。率先提出了人类蛋白质组计划的科学目标与技术路线,并领导揭示了人体首个器官(肝脏)的蛋白质组表达谱、乙酰化修饰谱及其相互作用连锁图、亚细胞器定位图;发现蛋白质组构成及丰度分布的三大规律:进化律、结构律与功能律。曾主持编写人类第一个器官(肝脏)的蛋白质组专著【The Liver Proteome(Wiley出版),在Science, Nat Genet, Nat Med, Nat Cell Biol, Nat Biotechnol, Nat Methods, , PNAS等国际核心刊物发表论文240篇。

 

发表文献:

 

1.      Zuo, Y., Ren, S., Wang, M., Liu, B., Yang, J., Kuai, X., Lin, C., Zhao, D., Tang, L., and He, F. Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver. Gut. 2013, 62(8):1169-78.

2.      Wang, X., Guo, B., Li, Q., Peng, J., Yang, Z., Wang, A., Li, D., Hou, Z., Lv, K., Kan, G., Cao, H., Wu, H., Song, J., Pan, X., Sun, Q., Ling, S., Li, Y., Zhu, M., Zhang, P., Peng, S., Xie, X., Tang, T., Hong, A., Bian, Z., Bai, Y., Lu, A., He, F., and Zhang, G. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013, 19(1):93-100.

3.      Liu, Z., Guo, F., Zhang, J., Wang, J., Lu, L., Li, D., and He, F. Proteome-wide prediction of self-interacting proteins based on multiple properties. Mol Cell Proteomics. 2013, 12(6):1689-700.

4.      Zhang, G., Guo, B., Wu, H., Tang, T., Zhang, B.T., Zheng, L., He, Y., Yang, Z., Pan, X., Chow, H., To, K., Li, Y., Li, D., Wang, X., Wang, Y., Lee, K., Hou, Z., Dong, N., Li, G., Leung, K., Hung, L., He, F., Zhang, L., and Qin, L. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Med. 2012, 18(2):307-14.

5.      Yang, D., Zhong, F., Li, D., Liu, Z., Wei, H., Jiang, Y., and He, F. General trends in the utilization of structural factors contributing to biological complexity. Mol Biol Evol. 2012, 29(8):1957-68.

6.      Song, S., Xing, G., Yuan, L., Wang, J., Wang, S., Yin, Y., Tian, C., He, F., and Zhang, L. N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents. Cell Res. 2012, 22(8):1285-303.

7.      Ling, S., Sun, Q., Li, Y., Zhang, L., Zhang, P., Wang, X., Tian, C., Li, Q., Song, J., Liu, H., Kan, G., Cao, H., Huang, Z., Nie, J., Bai, Y., Chen, S., and He, F. CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A. Circulation. 2012, 126(25):3028-40.

8.      Wang, J., Huo, K., Ma, L., Tang, L., Li, D., Huang, X., Yuan, Y., Li, C., Wang, W., Guan, W., Chen, H., Jin, C., Wei, J., Zhang, W., Yang, Y., Liu, Q., Zhou, Y., Zhang, C., Wu, Z., Xu, W., Zhang, Y., Liu, T., Yu, D., Chen, L., Zhu, D., Zhong, X., Kang, L., Gan, X., Yu, X., Ma, Q., Yan, J., Zhou, L., Liu, Z., Zhu, Y., Zhou, T., He, F., and Yang, X. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011, 7:536.

9.      Zhang, X., Yang, J., Guo, Y., Ye, H., Yu, C., Xu, C., Xu, L., Wu, S., Sun, W., Wei, H., Gao, X., Zhu, Y., Qian, X., Jiang, Y., Li, Y., and He, F. Functional proteomic analysis of nonalcoholic fatty liver disease in rat models: enoyl-coenzyme a hydratase down-regulation exacerbates hepatic steatosis. Hepatology. 2010, 51(4):1190-9.

10.   Zhang, H., Zhai, Y., Hu, Z., Wu, C., Qian, J., Jia, W., Ma, F., Huang, W., Yu, L., Yue, W., Wang, Z., Li, P., Zhang, Y., Liang, R., Wei, Z., Cui, Y., Xie, W., Cai, M., Yu, X., Yuan, Y., Xia, X., Zhang, X., Yang, H., Qiu, W., Yang, J., Gong, F., Chen, M., Shen, H., Lin, D., Zeng, Y.X., He, F., and Zhou, G. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet. 2010, 42(9):755-8.

 


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